HEXOKINASE 2 DEPLETION CONFERS SENSITIZATION TO METFORMIN AND INHIBITS GLYCOLYSIS IN LUNG SQUAMOUS CELL CARCINOMA

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets.Compared with lung adenocarcinoma (ADCs), lung SCCs reportedly utilized higher levels of glucose metabolism to meet the anabolic and catabolic needs required to sustain rapid tumor gr

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From macro-level policies to microlevel practices

In recent decades, gated communities for affluent groups have gained academic attention worldwide.However, in nations with large inequalities such as Mexico, which are also affected by issues of insecurity, corruption, and violence, these enclaves have become more common for middle-income groups.Their existence is usually associated with the search

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Evaluation of Ground Motion Amplification Effects in Slope Topography Induced by the Arbitrary Directions of Seismic Waves

The incident directions of seismic waves can change the ground motions of slope topography.To elaborate on the influences of the directions of seismic waves, a dynamic analysis of the slope topography was performed.Seismic waves were input using an equivalent nodal force method combined with a viscous-spring artificial boundary.The amplification of

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